Thursday, May 29, 2008

Duplicate welcome screen icon in Vista

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Authentication\Credential Providers\

There is one empty authenticated ID started with "6f45dc1e"

Delete it!

Tuesday, May 27, 2008

A Half-Dozen Ways to Get TV on the Go - US News and World Report

A Half-Dozen Ways to Get TV on the Go - US News and World Report: "A Half-Dozen Ways to Get TV on the Go"

When did TV become such a big part of our life that everyone would want to be able to watch it all the time?

Sunday, May 25, 2008

What made another GWAS for Diabetest still interesting?: "A Polymorphism Within the G6PC2 Gene Is Associated with Fasting Plasma Glucose Levels"

It was quite surprising to me to see Science published GWAS result for diabetes one after another. After reading the detail, these seems to be what make the difference.

1. In addition to the genotyped SNPs, HapMap imputation of ungenotyped SNPs seem to be on every GWAS todo list, right now -> they, however, didn't find anything new, which was not very surprising if they genotyping platform had a well-coverage of HapMap. All the tag SNPs should be there or at least were tagged with some SNPs. Doing imputation which uses info from genotyped SNPs wouldn't give much more information about untyped SNPs in this case.

2. Replication: another must do list for any good journal. Of course, unless you replicated the result. Your paper is probably going to a trash bin. Not to mention that your result have to survive genome-wide significant level (5x10-8) to be interesting. (French DESIR cohort, Northern Finland Birth Cohort,

3. They were not just looking at FPG, but also all the possible intermediate phenotypes for DM e.g. HOMA-Index for insulin secretion. It was quite upset to see no functional study result but only an extensive discussion of the gene function in glucose homeostasis, although from skimming through the text, it seems like they had a result from functional study of the gene in detail. So, I think if you are lucky enough to find a gene that already has been studied, you will have something more to discuss, and you will also can test for those intermediate phenotypes in your study population as they did in this paper.

Sunday, May 04, 2008

Long-awaited electric sports car rolls out - CNN.com

Long-awaited electric sports car rolls out - CNN.com:

"After several years of development, the Roadster -- with sleek lines like a Ferrari or Porsche and a sticker price of $109,000"

Umm, what reasoning do you have to use to buy this car? It costs over 100k, and the battery life can last for only 100,000 miles. A dollar per mile is probably not as bad as it sounds, but that means on average you pay 20,000$/year to drive this carbon-fiber car! With a fully-charged battery, you can drive 225 miles. Then, you will have to recharge it again for 3.5h before you can drive another 225miles.

What will happen next after the battery dies out? Do you have to throw the car away?What will you do with tons of Lithium ion battery? Will we end up building anther hazard waste and dump it somewhere like "DEVELOPING COUNTRIES"?
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